Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (37)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nadrous, H. F.
Right arrow Articles by Ryu, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nadrous, H. F.
Right arrow Articles by Ryu, J. H.
(Chest. 2005;128:2393-2399.)
© 2005 American College of Chest Physicians

Pulmonary Hypertension in Patients With Idiopathic Pulmonary Fibrosis*

Hassan F. Nadrous, MD; Patricia A. Pellikka, MD; Michael J. Krowka, MD; Karen L. Swanson, DO; Nithima Chaowalit, MD; Paul A. Decker, MS and Jay H. Ryu, MD, FCCP

* From the Division of Pulmonary, Critical Care, and Internal Medicine (Drs. Nadrous and Ryu), Division of Cardiovascular Diseases (Drs. Chaowalit and Pellikka), Department of Health Sciences Research (Mr. Decker), and Pulmonary Hypertension Clinic (Drs. Krowka and Swanson), Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN.

Correspondence to: Jay H. Ryu, MD, FCCP, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: ryu.jay{at}mayo.edu


   Abstract
TOP
 Abstract
Introduction
 Materials and Methods
 Results
 Discussion
 Conclusions
 References
 
Study objectives: To determine the impact on survival and clinical correlates of pulmonary hypertension (PH) occurring in patients with idiopathic pulmonary fibrosis (IPF).

Design: Retrospective study.

Setting: Tertiary care, referral medical center.

Patients: Among 487 consecutive patients with IPF, we identified 136 patients who underwent transthoracic echocardiography within 3 months of their initial evaluation at our institution. Patients with left ventricular dysfunction, valvular heart disease, incomplete follow-up, and those in whom pulmonary artery pressures could not be assessed were excluded; the remaining 88 patients were included in this study. Correlations were performed between echocardiographic measures of PH and clinical variables including survival.

Measurements and results: The mean (± SD) estimated systolic pulmonary artery pressure (SPAP) for the 88 patients was 48 ± 16 mm Hg (range, 28 to 116 mm Hg). Among pulmonary function parameters, SPAP correlated best with diffusing capacity of the lung for carbon monoxide (DLCO), to which it was inversely related. For survival analysis, patients were stratified into three groups: ≤ 35 mm Hg (14 patients), 36 to 50 mm Hg (47 patients), and > 50 mm Hg (27 patients). Using the Kaplan-Meier method, the median survival rates for these three groups were 4.8 years, 4.1 years, and 0.7 years, respectively. Those patients with SPAP > 50 mm Hg had significantly worse survival compared to other subgroups (p = 0.009).

Conclusion: In patients with IPF, PH correlates inversely with DLCO and has a significant adverse impact on survival, particularly when SPAP is > 50 mm Hg.

Key Words: echocardiography • idiopathic pulmonary fibrosis • prognosis • pulmonary hypertension


   Introduction
TOP
 Abstract
 Introduction
Materials and Methods
 Results
 Discussion
 Conclusions
 References
 
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive parenchymal lung disease of unknown cause with an underlying histopathologic pattern of usual interstitial pneumonia.1234 To our knowledge, no effective medical treatment exists for this disorder.1234 The overall prognosis is poor, with a median survival of < 3 years.1256

Although IPF is associated with a poor prognosis, there is survival heterogeneity that is difficult to predict for individual patients.1256 Multiple studies6789101112 have attempted to identify clinical and physiologic predictors of survival and have yielded variable and sometimes contradictory results. Although the occurrence of pulmonary hypertension (PH) in patients with IPF is recognized, the clinical implications of this association have not been clear.1314 Additionally, revisions to the diagnostic criteria for IPF2 warrant a reexploration of this issue. In the present report, we sought to determine the impact on survival and clinical correlates of PH occurring in patients with IPF.


   Materials and Methods
TOP
 Abstract
 Introduction
 Materials and Methods
Results
 Discussion
 Conclusions
 References
 
Study Population
This study was approved by the Mayo Foundation institutional review board. Using a computer-assisted search, 487 patients with IPF evaluated at Mayo Clinic Rochester during the period of January 1, 1994, to December 31, 1996, were identified.15 The clinical, radiologic, and physiologic features for this population have been published previously.15 Of these 487 patients, 136 patients (28%) underwent a comprehensive echocardiographic evaluation within 3 months of their initial visit at our medical center (index visit), and the study was available for current review. From this group of 136 patients, 48 patients were excluded for the following reasons: systolic pulmonary artery pressure (SPAP) not obtainable (25 patients), left ventricular ejection fraction < 40% (17 patients), valvular heart disease (3 patients), and incomplete follow-up (3 patients). The median survival of patients in whom SPAP was unobtainable was 2.3 years; the median survival of patients with left ventricular ejection fraction < 40% was 1.4 years. The remaining 88 patients were included in this study. The mean (± SD) interval betweenechocardiography and the index visit was 3.3 ± 8.2 days.

All 88 patients included in this study manifested characteristic clinical features of IPF plus either typical high-resolution CT findings (n = 71) and/or histopathologic evidence on surgical lung biopsy specimen for usual interstitial pneumonia (n = 17) as described in the American Thoracic Society/European Respiratory Society consensus definition for IPF.2 The medical records were carefully reviewed to exclude known causes of PH, including prior venous thromboembolism, HIV infection, systemic vasculitis or other connective tissue diseases, chronic liver disease with portal hypertension, left ventricular dysfunction, and history of anorexigenic drugs.

Clinical Data Collection
The clinical data, laboratory results, pulmonary function data, high-resolution CT results, and bronchoscopy and lung biopsy results from the initial evaluation at our medical center were extracted from the medical records. Treatments for IPF prior to and after the index visit date, including oxygen therapy, were also recorded. We determined the vital status of patients by reviewing medical records and death certificates as well as by telephone interviews.

Pulmonary function testing was performed using daily calibrated equipment (models 1070 and 1085; Medical Graphics; St. Paul, MN) according to American Thoracic Society specifications as previously described.15 The pulmonary function tests included lung volumes with total lung capacity, spirometry including FVC and FEV1, diffusion capacity of the lung for carbon monoxide (DLCO), oxygen saturation at rest and with exercise, and arterial blood gas analysis at rest and with exercise. Baseline pulmonary function testing was defined as the test performed at our medical center closest to the index visit, limited to tests within 90 prior or 14 days following the index visit date.

Transthoracic Echocardiography: Doppler and Color Flow Imaging
Two-dimensional transthoracic echocardiography, pulsed and continuous-wave Doppler, and color flow imaging were performed in all patients using previously described techniques.1617 The echocardiographic studies were reviewed by two cardiologists (N.C., P.A.P.) who were unaware of the clinical data. Pulmonary arterial hypertension was defined as a SPAP > 35 mm Hg at rest. SPAP was calculated based on the modified Bernoulli equation, and right atrial pressure was estimated as 5, 10, 15, or 20 mm Hg, on the basis of the size and respiratory change of the inferior vena cava using previously described techniques.1819 Right atrial and ventricular size along with right ventricular hypertrophy and systolic function were scored semiquantitatively on a scale of 0 (normal), 1 (mildly impaired or enlarged), 2 (moderately impaired or enlarged), or 3 (severely impaired or enlarged). Left ventricular dimensions, ejection fraction, and cardiac index were obtained by previously recommended techniques.20

Statistical Analysis
Baseline characteristics were compared across the three SPAP subgroups (≤ 35 mm Hg, 36 to 50 mm Hg, and > 50 mm Hg) using an exact test for discrete variables and the Kruskal-Wallis test for continuous variables. A Spearman correlation coefficient was used to examine the association of SPAP with pulmonary function parameters and echocardiographic test results. For survival analysis, time zero is defined as the index visit, which was the date the patient was first seen at our medical center during the original study period (January 1, 1994, to December 31, 1996). Cumulative survival probabilities were estimated using the Kaplan-Meier method.21 Cox proportional hazards regression was used to identify variables associated with survival.22 Potential predictors considered in the survival analysis included age at index visit, gender, smoking status (current or former vs never), New York Heart Association (NYHA) functional status, history of coronary artery disease, history of congestive heart failure, history of hypertension or a history of diabetes mellitus, digital clubbing, treatment (any vs none), oxygen use prior to index visit, SPAP, estimated cardiac output, estimated cardiac index, estimated right atrial pressure, percentage of predicted FVC, percentage of predicted DLCO, and percentage of predicted FEV1. Oxygen saturation at rest and exercise as well as PaO2, PaCO2, and alveolar-arterial oxygen gradient at rest were not used in the survival analysis because these measures were not consistently obtained. In all cases, p < 0.05 was considered statistically significant.


   Results
TOP
 Abstract
 Introduction
 Materials and Methods
 Results
Discussion
 Conclusions
 References
 
Clinical Characteristics of IPF Patients With PH
The clinical characteristics of the 88 patients are summarized in Table 1 . The mean estimated SPAP for the entire group was 48 ± 16 mm Hg (range, 28 to 116 mm Hg). Evidence of PH (SPAP > 35 mm Hg at rest) was present in 74 patients (84%). Patients were stratified by SPAP into three subgroups: ≤ 35 mm Hg, 36 to 50 mm Hg, and > 50 mm Hg, and included 14 patients (16%), 47 patients (53%), and 27 patients (31%), respectively. The three groups were similar except for gender, NYHA functional status, history of congestive heart failure, and oxygen use prior to index visit. Patients with SPAP > 50 mm Hg were more likely to be men, have a worse NYHA functional status and a history of congestive heart failure, and receive supplemental oxygen.


View this table:
[in this window]
[in a new window]

  		Table 1.. Demographic and Clinical Characteristics in SPAP Subgroups*

 
Echocardiographic Findings
The echocardiographic findings of the 88 patients with IPF are summarized in Table 2 . Right atrial and right ventricular enlargement were found in 20 patients (23%) and 18 patients (20%), respectively. Right ventricular systolic function was impaired in 10 patients (11%). On the basis of color flow imaging, tricuspid regurgitation was present in 56 patients (64%). Continuous-wave Doppler study was satisfactory for evaluation of SPAP in all 88 patients. The median peak velocity of tricuspid regurgitation was 2.9 ± 0.6 m/s (range, 2.0 to 4.9 m/s). Twenty-seven patients (31%) had an estimated SPAP > 50 mm Hg. Among 14 patients who had an estimated SPAP ≤ 35 mm Hg, none had right atrial or right ventricular enlargement or an impaired right ventricular function. Of 10 patients with an impaired right ventricular systolic function, 8 patients had an estimated SPAP > 60 mm Hg. The mean left ventricular ejection fraction was 60 ± 8% (range, 40 to 79%). Of 88 patients, 5 patients had minimal pericardial effusion without evidence of cardiac tamponade. Two patients had patent foramen ovale with trivial shunt.


View this table:
[in this window]
[in a new window]

  		Table 2.. Echocardiographic Findings by SPAP Subgroups*

 
Correlation of Pulmonary Function With Echocardiographic Measures of PH
All 88 patients had pulmonary function testing (Table 3 ). The patients with SPAP > 50 mm Hg had more impaired DLCO and PaO2, but no other significant differences were found among the three subgroups. There was an inverse correlation between DLCO and SPAP (r = –0.47, p < 0.001). There was also an inverse correlation between SPAP and PaO2 at rest (r = –0.36, p = 0.007) and oxygen saturation at rest (r = –0.33, p = 0.013), as well as a direct correlation with the alveolar-arterial oxygen tension gradient at rest (r = 0.29, p = 0.035). None of the remaining indexes of pulmonary function including FVC, FEV1, and FEV1/FVC correlated with echocardiographic-derived SPAP.


View this table:
[in this window]
[in a new window]

  		Table 3.. Baseline Pulmonary Function Data by SPAP Subgroups*

 
Survival
The median and estimated 1-year and 3-year survival rates for the three subgroups are as follows: ≤ 35 mm Hg (median, 4.8 years; 1 year = 100%; 95% confidence interval [CI], 100 to 100%; 3 year = 64%; 95% CI, 44 to 95%); 36 to 50 mm Hg (median, 4.1 years; 1 year = 79%; 95% CI, 68 to 91%; 3 year = 61%; 95% CI, 49 to 77%); and > 50 mm Hg (median, 0.7 years; 1 year = 44%; 95% CI, 29 to 68%; 3 year = 32%; 95% CI, 19 to 57%) [Fig 1 ]. Increased SPAP was associated with shortened survival (relative risk [RR], 1.34 per 10 mm Hg increase; 95% CI, 1.17 to 1.53; p < 0.001). Univariate analysis for the entire cohort also demonstrated shorter survival to be associated with male gender (RR, 2.6; 95% CI, 1.37 to 4.95; p = 0.004), oxygen use prior to index visit (RR, 1.90; 95% CI, 1.02 to 3.51; p = 0.042), lower DLCO (RR, 1.61 per 10 percentage point decrease; 95% CI, 1.26 to 2.04; p < 0.001), history of coronary artery disease (RR, 1.96; 95% CI, 1.13 to 3.40; p = 0.017), and worse NYHA class (RR, 1.62; 95% CI, 1.17 to 1.53; p = 0.044).



View larger version (13K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 1.. Kaplan-Meier survival curve for 88 IPF patients stratified by their SPAP.

 

   Discussion
TOP
 Abstract
 Introduction
 Materials and Methods
 Results
 Discussion
Conclusions
 References
 
This study describes echocardiographic characteristics and survival of patients with PH associated with IPF. Our data suggest that significant PH is not limited to patients with advanced IPF. SPAP correlated inversely with DLCO. The estimated survival from the time of IPF diagnosis of patients with SPAP > 50 mm Hg was substantially worse than that of patients with SPAP ≤ 50 mm Hg. PH is likely more common than currently suspected in patients with IPF and has prognostic and management implications. This subgroup of patients may warrant more aggressive management or early referral for lung transplantation.

Secondary PH is more common than primary PH, and there is a consensus that PH in patients with interstitial lung disease is associated with worse survival. However, little has been known about the association between PH and IPF.23 Effective treatment of PH may prolong survival in patients who have IPF and PH. The major obstacle in treating PH has been the limited availability of oral or IV drugs that affect the pulmonary vasculature without causing excessive systemic vasodilation or increasing ventilation-perfusion mismatching.2324 With the increasing availability of drugs for the treatment of PH such as bosentan,25 sitaxsentan,2627 treprostinil,28 iloprost,29 beraprost,30 sildenafil3132 in addition to epoprostenol,33 it may be reasonable to explore their role further in treating PH associated with IPF.

It has been difficult to accurately predict the clinical course in individual patients with IPF.12 Published studies67891934 have identified several demographic (age, sex, smoking), physiologic (DLCO, FVC), radiologic, and histopathologic features (eg, fibroblastic foci), and combinations of these parameters that correlate with survival. However, conclusions from these studies67891934 have not been entirely consistent. Other studies have examined the association between survival of patients with IPF and the trends in pulmonary function over time. Flaherty et al11 found a decrease of > 10% in FVC over a 6-month follow-up period to be an independent risk factor for mortality. Collard et al10 showed that changes in clinical as well as physiologic variables over 6-month and 12-month periods are predictive of survival and provide more accurate prognostic information than baseline values alone. Latsi et al12 also showed that serial pulmonary function trends have considerable prognostic value, not only for patients with IPF but also in patients with fibrotic nonspecific interstitial pneumonia.

The prevalence and prognostic significance of PH in patients with IPF as well as the impact of therapy for PH on these patients needs to be explored further. Harari et al13 examined the prognostic value of PH in patients with chronic interstitial lung disease referred for lung transplantation including 43 patients with "IPF" and found that neither hemodynamic nor respiratory parameters obtained during the preoperative clinical screening predicted survival. In addition, there was no correlation between pulmonary function parameters and PH in these patients. However, the mean survival of these patients with advanced lung disease in their study was short (5.67 ± 0.42 months), making the detection of any impact of PH on survival difficult. In contrast, Jezek14 noted PH to have a significant impact on survival of patients with "idiopathic diffuse interstitial lung fibrosis."

An important limitation of this study is its retrospective design and the lack of right-heart catheterization to confirm the presence and degree of PH. These patients underwent echocardiography for a variety of reasons, and potential biases exist based on this selection process. In addition, there are recognized limitations to the use of echocardiography in evaluating PH in patients with advanced lung disease.3536 Care must be taken to align the Doppler beam with the direction of flow or underestimation of the pulmonary artery pressure may result. Even if there is insufficient tricuspid regurgitation to allow measurement of pulmonary artery pressure, it cannot be assumed that the pulmonary artery pressure is normal. With these caveats, Doppler echocardiography is a convenient, noninvasive, and relatively accurate tool for evaluating PH.16173738 A recent study39 suggests that plasma level of brain natriuretic peptide may be a predictor of moderate to severe PH in patients with pulmonary fibrosis. Interestingly, lung function parameters did not correlate with brain natriuretic peptide level or the presence of PH. Plasma brain natriuretic peptide level and echocardiography may have complementary roles in the evaluation of patients with IPF.


   Conclusions
TOP
 Abstract
 Introduction
 Materials and Methods
 Results
 Discussion
 Conclusions
References
 
Our data demonstrate that SPAP correlates inversely with DLCO and PH has a significant adverse impact on survival, particularly when SPAP is > 50 mm Hg. Further studies are needed to define the prevalence of PH as well as management implications for patients with IPF.


   Footnotes
 
Abbreviations: CI = confidence interval; DLCO = diffusing capacity of the lung for carbon monoxide; IPF = idiopathic pulmonary fibrosis; NYHA = New York Heart Association; PH = pulmonary hypertension; RR = relative risk; SPAP = systolic pulmonary artery pressure

Dr. Chaowalit was supported by Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Received for publication December 14, 2004. Accepted for publication February 17, 2005.


   References
TOP
 Abstract
 Introduction
 Materials and Methods
 Results
 Discussion
 Conclusions
 References
 

  1. Ryu, JH, Colby, TV, Hartman, TE (1998) Idiopathic pulmonary fibrosis: current concepts. Mayo Clin Proc 73,1085-1101[ISI][Medline]
  2. American Thoracic Society/European Respiratory Society. Idiopathic pulmonary fibrosis: diagnosis and treatment; international consensus statement. Am J Respir Crit Care Med 2000;161,646-664[Free Full Text]
  3. Gross, TJ, Hunninghake, GW Idiopathic pulmonary fibrosis. N Engl J Med 2001;345,517-525[Free Full Text]
  4. American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2002;165,277-304[Free Full Text]
  5. Bjoraker, JA, Ryu, JH, Edwin, MK, et al Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998;157,199-203
  6. King, TE, Jr, Tooze, JA, Schwarz, MI, et al Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model. Am J Respir Crit Care Med 2001;164,1171-1181[Abstract/Free Full Text]
  7. Schwartz, DA, Helmers, RA, Galvin, JR, et al Determinants of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1994;149,450-454[Abstract]
  8. Erbes, R, Schaberg, T, Loddenkemper, R Lung function tests in patients with idiopathic pulmonary fibrosis: are they helpful in predicting outcome? Chest 1997;111,51-57[Abstract/Free Full Text]
  9. Mogulkuc, N, Brutshe, MH, Bishop, PW, et al Pulmonary function in idiopathic pulmonary fibrosis and referral for lung transplantation. Am Rev Respir Crit Care Med 2001;164,103-108[Abstract/Free Full Text]
  10. Collard, HR, King, TE, Jr, Bartelson, BB, et al Changes in clinical and physiologic variables predict survival in idiopathic and pulmonary fibrosis. Am J Respir Crit Care Med 2003;168,538-542[Abstract/Free Full Text]
  11. Flaherty, KR, Mumford, JA, Murray, S, et al Prognostic implications of physiologic and radiographic changes in idiopathic interstitial pneumonia. Am J Respir Crit Care Med 2003;168,543-548[Abstract/Free Full Text]
  12. Latsi, PI, du Bois, RM, Nicholson, AG, et al Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends. Am J Respir Crit Care Med 2003;168,531-537[Abstract/Free Full Text]
  13. Harari, S, Simonneau, G, De Juli, E, et al Prognostic value of pulmonary hypertension in patients with chronic interstitial lung disease referred for lung or heart-lung transplantation. J Heart Lung Transplant 1997;16,460-463[ISI][Medline]
  14. Jezek, V The prognosis and development of pulmonary hypertension in idiopathic diffuse interstitial lung fibrosis. Giornale Ital Cardiol 1984;14(suppl 1),39-45
  15. Douglas, WW, Ryu, JH, Schroeder, DR Idiopathic pulmonary fibrosis: impact of oxygen and colchicine, prednisone or no therapy on survival. Am J Respir Crit Care Med 2000;161,1172-1178[Abstract/Free Full Text]
  16. Tajik, AJ, Seward, JB, Hagler, DJ, et al Two-dimensional real-time ultrasonic imaging of the heart and great vessels: technique, image orientation, structure identification, and validation. Mayo Clin Proc 1978;53,271-303[ISI][Medline]
  17. Nishimura, RA, Miller, FA, Jr, Callahan, MJ, et al Doppler echocardiography: theory, instrumentation, technique, and application. Mayo Clin Proc 1985;60,321-343[ISI][Medline]
  18. Currie, PJ, Seward, JB, Chan, KL, et al Continuous wave Doppler determination of right ventricular pressure: a simultaneous Doppler-catheterization study in 127 patients. J Am Coll Cardiol 1985;6,750-756[Abstract]
  19. Kircher, BJ, Himelman, RB, Schiller, NB Noninvasive estimation of right atrial pressure from the inspiratory collapse of the inferior vena cava. Am J Cardiol 1990;66,493-496[CrossRef][ISI][Medline]
  20. Schiller, NB, Shah, PM, Crawford, M, et al American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. J Am Soc Echocardiogr 1989;2,358-367[Medline]
  21. Kaplan, EL, Meier, P Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958;53,457-481[CrossRef][ISI]
  22. Cox, DR Regression models and life-tables. J R Stat Soc 1972;Series B,187-220
  23. Maloney, JP Advances in the treatment of secondary pulmonary hypertension. Curr Opin Pulm Med 2003;9,139-143[CrossRef][ISI][Medline]
  24. Shapiro, S Management of pulmonary hypertension resulting from interstitial lung disease. Curr Opin Pulm Med 2003;9,426-430[CrossRef][ISI][Medline]
  25. Rubin, LJ, Badesch, DB, Barst, RJ, et al Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 2002;346,896-903[Abstract/Free Full Text]
  26. Barst, RJ, Langleben, D, Frost, A, the STRIDE-1 Study Group. et al Sitaxsentan therapy for pulmonary arterial hypertension. Am J Respir Crit Care Med 2004;169,441-447[Abstract/Free Full Text]
  27. Barst, RJ, Rich, S, Widlitz, A, et al Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension: open-label pilot study. Chest 2002;121,1860-1868[Abstract/Free Full Text]
  28. Simonneau, G, Barst, RJ, Galie, N, the Treprostinil Study Group. et al Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care M 2002;165,800-804
  29. Hoeper, MM, Schwarze, M, Ehlerding, S, et al Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N Engl J Med 2000;342,1866-1870[Abstract/Free Full Text]
  30. Galie, N, Humbert, M, Vachiery, JL, the Arterial Pulmonary Hypertension and Beraprost European (ALPHABET) Study Group. et al Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol 2002;39,1496-1502[Abstract/Free Full Text]
  31. Wilkens, H, Guth, A, Konig, J, et al Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation 2001;104,1218-1222[Abstract/Free Full Text]
  32. Michelakis, E, Tymchak, W, Lien, D, et al Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide. Circulation 2002;105,2398-2403[Abstract/Free Full Text]
  33. Badesch, DB, Tapson, VF, McGoon, MD, et al Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease: a randomized, controlled trial. Ann Intern Med 2000;132,425-434[Abstract/Free Full Text]
  34. Nicholson, AG, Fulford, LG, Colby, TV, et al The relationship between individual histologic features and disease progression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2002;166,173-177[Abstract/Free Full Text]
  35. Arcasoy, SM, Christie, JD, Ferrari, VA, et al Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease. Am J Respir Crit Care Med 2003;167,735-740[Abstract/Free Full Text]
  36. Homma, A, Anzueto, A, Peters, JI Pulmonary artery systolic pressures estimated by echocardiogram vs cardiac catheterization in patients awaiting lung transplantation. J Heart Lung Transplant 2001;20,833-839[CrossRef][ISI][Medline]
  37. Gladwin, MT, Sachdev, V, Jison, ML, et al Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med 2004;350,886-895[Abstract/Free Full Text]
  38. McGoon, M, Gutterman, D, Steen, V, et al Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 2004;126,14S-34S[Abstract/Free Full Text]
  39. Leuchte, HH, Neurohr, C, Baumgartner, R, et al Brain natriuretic peptide and exercise capacity in lung fibrosis and pulmonary hypertension. Am J Respir Crit Care Med 2004;170,360-365[Abstract/Free Full Text]



This article has been cited by other articles:


Home page
 ChestHome page
D. A. Zisman, A. S. Karlamangla, S. M. Kawut, O. A. Shlobin, R. Saggar, D. J. Ross, M. I. Schwarz, J. A. Belperio, A. Ardehali, J. P. Lynch III, et al.
Validation of a Method To Screen for Pulmonary Hypertension in Advanced Idiopathic Pulmonary Fibrosis
Chest, March 1, 2008; 133(3): 640 - 645.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. K. Han, V. V. McLaughlin, G. J. Criner, and F. J. Martinez
Pulmonary Diseases and the Heart
Circulation, December 18, 2007; 116(25): 2992 - 3005.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. M. Taveira-DaSilva, O. M. Hathaway, V. Sachdev, Y. Shizukuda, C. W. Birdsall, and J. Moss
Pulmonary Artery Pressure in Lymphangioleiomyomatosis: An Echocardiographic Study
Chest, November 1, 2007; 132(5): 1573 - 1578.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
N. M. Patel, D. J. Lederer, A. C. Borczuk, and S. M. Kawut
Pulmonary Hypertension in Idiopathic Pulmonary Fibrosis
Chest, September 1, 2007; 132(3): 998 - 1006.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. A. Zisman, A. S. Karlamangla, D. J. Ross, M. P. Keane, J. A. Belperio, R. Saggar, J. P. Lynch III, A. Ardehali, and J. Goldin
High-Resolution Chest CT Findings Do Not Predict the Presence of Pulmonary Hypertension in Advanced Idiopathic Pulmonary Fibrosis
Chest, September 1, 2007; 132(3): 773 - 779.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
I. Noth and F. J. Martinez
Recent Advances in Idiopathic Pulmonary Fibrosis
Chest, August 1, 2007; 132(2): 637 - 650.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Alakhras, P. A. Decker, H. F. Nadrous, M. Collazo-Clavell, and J. H. Ryu
Body Mass Index and Mortality in Patients With Idiopathic Pulmonary Fibrosis
Chest, May 1, 2007; 131(5): 1448 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. D. Fell and F. J. Martinez
The Impact of Pulmonary Arterial Hypertension on Idiopathic Pulmonary Fibrosis
Chest, March 1, 2007; 131(3): 641 - 643.
[Full Text] [PDF]

Home page
 ChestHome page
S. D. Nathan, O. A. Shlobin, S. Ahmad, S. Urbanek, and S. D. Barnett
Pulmonary Hypertension and Pulmonary Function Testing in Idiopathic Pulmonary Fibrosis
Chest, March 1, 2007; 131(3): 657 - 663.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. Hamada, S. Nagai, S. Tanaka, T. Handa, M. Shigematsu, T. Nagao, M. Mishima, M. Kitaichi, and T. Izumi
Significance of Pulmonary Arterial Pressure and Diffusion Capacity of the Lung as Prognosticator in Patients With Idiopathic Pulmonary Fibrosis
Chest, March 1, 2007; 131(3): 650 - 656.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Strange
Treatment for Secondary Pulmonary Hypertension
Chest, October 1, 2005; 128(4): 1897 - 1898.
[Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (37)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nadrous, H. F.
Right arrow Articles by Ryu, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nadrous, H. F.
Right arrow Articles by Ryu, J. H.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS