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Panton-Valentine Leukocidin-Positive Methicillin-Resistant Staphylococcus aureus Lung Infections in Patients with Cystic Fibrosis

¹Departments of Pediatrics, Medicine ²Pathology and Immunology ³and the Genome Sequencing Center ⁴Washington University School of Medicine, St. Louis, MO 63110, U.S.A

Elizur_A{at}kids.wustl.edu

Abstract

Background: Panton-Valentine Leukocidin-expressing, methicillin-resistant Staphylococcus aureus (PVL⁺ MRSA) is an emerging pathogen world-wide causing fatal necrotizing pneumonias in otherwise healthy individuals, but has not been described in CF patients. Following two cases of patients with CF admitted with lung abscesses in association with PVL⁺ MRSA, we examined the incidence and the clinical characteristics of MRSA acquisition in our CF patient population.

Methods: Newly acquired MRSA isolates from patients with CF followed at St. Louis Children's Hospital were analyzed for the presence of PVL coding region, clindamycin susceptibility, staphylococcal cassette chromosome (SCC) mec type, and multi-locus sequence type. Medical records and pulmonary function studies at the time of MRSA isolation were reviewed.

Results: MRSA isolates from 40 CF patients were available for analysis. Six children (15%) were infected with PVL⁺ MRSA. All PVL+ organisms were clindamycin susceptible. Patients who acquired a PVL⁺ organism were more likely to have a focal pulmonary infiltrate on chest radiograph including cavitary lung lesions in two patients (p = 0.04), a markedly greater decline in FEV1 at the time of MRSA detection (p = 0.01), and a significantly higher WBC (p = 0.04) and absolute neutrophil count (p = 0.04). These patients were more likely to be admitted for intravenous antibiotic therapy for respiratory illnesses (p < 0.01).

Conclusions: We describe the emergence of PVL⁺ MRSA in our CF population in association with development of invasive lung infections including lung abscesses. Early identification and treatment of CF patients with newly acquired PVL⁺ MRSA may be crucial.

Key Words: Cystic fibrosis • Lung abscess • Staphylococcus

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				D. Glikman, J. D. Siegel, M. Z. David, N. M. Okoro, S. Boyle-Vavra, M. L. Dowell, and R. S. Daum Complex Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Isolates From Children With Cystic Fibrosis in the Era of Epidemic Community-Associated Methicillin-Resistant S aureus Chest, June 1, 2008; 133(6): 1381 - 1387. [Abstract] [Full Text] [PDF]