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This Article Full Text (PDF) Free online supplement All Versions of this Article: chest.07-0035v1 132/2/547    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Personal Article Archive Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Yegen, H. A. Articles by Kawut, S. M. Search for Related Content PubMed PubMed Citation Articles by Yegen, H. A. Articles by Kawut, S. M.

Risk Factors for Venous Thromboembolism after Lung Transplantation

¹New York Presbyterian Hospital Lung Transplant Program, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY ²Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY ³Department of Statistics, Graduate School of Arts and Sciences, Columbia University, New York, NY ⁴Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY ⁵Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY ⁶Authors contributed equally to this paper

sk2097{at}columbia.edu

Abstract

BackgroundThe risk factors for venous thromboembolism following lung transplantation are not well established. We aimed to estimate the incidence of venous thromboembolism and to identify risk factors for venous thromboembolism after lung transplantation.

MethodsWe performed a nested case-control study within the cohort of 121 patients who underwent lung transplantation at our center between August 2001 and July 2005. Controls were matched to cases on days from transplant. Cox proportional hazards models were used to identify risk factors for venous thromboembolism.

ResultsTwenty-four patients had deep vein thromboses and 6 had pulmonary emboli (three had both) (22% of the cohort). In multivariate models, older age (p = 0.03), diabetes mellitus (p = 0.03), and pneumonia (p = 0.02) were associated with a higher rate of venous thromboembolism.

ConclusionsVenous thromboembolism is a frequent complication of lung transplantation. Older age, diabetes, and pneumonia increase the rate of venous thromboembolism. Future studies of intensive venous thromboembolism prophylaxis may be warranted.

Key Words: Lung transplantation • Pulmonary embolism • Venous thrombosis