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The relationship between the components of pulmonary artery pressure remains constant under all conditions in both health and disease.

Scottish Pulmonary Vascular Unit, Western Infirmary, Glasgow, UK ¹Department of Pediatrics, University of Colorado Health Sciences Centre, Denver USA ²Department of Respiratory Medicine, Victoria Infirmary, Glasgow UK

apeacock{at}udcf.gla.ac.uk

Abstract

Background: The relationship between systolic, diastolic, and mean pulmonary artery pressure was recently found to be constant in humans breathing air, at rest, whilst supine. It would be important for those studying the pulmonary circulation if this relationship were maintained under other circumstances, such as change in posture, on exercise or after pharmacological manipulation. In particular it would be useful if the relationship were maintained when treating pulmonary hypertension because this would allow different methods of measurement to be compared such as systolic pulmonary artery pressure from echocardiography and mean pulmonary artery pressure from right heart catheterisation. Methods. Data were reviewed from both normal subjects and those with pulmonary hypertension (n=65) who had a micromanometer tipped high fidelity pulmonary artery catheter inserted for between 6-36 hours in the Scottish Pulmonary Vascular Unit between 1997-2003. Five minute averages, whilst supine at rest, were analysed by linear regression, to compare the response of systolic pulmonary artery pressure (SPAP) and diastolic pulmonary artery pressure (DPAP) with mean pulmonary artery pressure (MPAP). Results. There were linear relationships (mmHg) of SPAP with MPAP (SPAP = 1.50 MPAP + 0.46), and DPAP with MPAP (DPAP = 0.71 MPAP - 0.66). These were maintained with a high degree of accuracy following changes in posture and activity. Conclusions. Systolic, mean and diastolic pulmonary artery pressures were strongly related and these relationships were maintained under varying conditions. This finding will allow comparison between invasive and non-invasive descriptions of pulmonary hemodynamics found in the literature.

Key Words: Ambulatory Monitoring • Pulmonary Artery Pressure • Pulmonary Hypertension

Related Editorial

Estimation of Mean Pulmonary Artery Pressure: Simpler Than Expected

Denis Chemla and Philippe Hervé
Chest 2008 133: 592-593. [Full Text] [PDF]

This article has been cited by other articles:

				D. Chemla and P. Herve Estimation of Mean Pulmonary Artery Pressure: Simpler Than Expected Chest, March 1, 2008; 133(3): 592 - 593. [Full Text] [PDF]