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RECENT ADVANCES IN CHEST MEDICINE: D. Kyle Hogarth and Gary Rachelefsky Screening and Familial Testing of Patients for 1-Antitrypsin Deficiency Chest 2008; 133: 981-988 [Abstract] [Full text] [PDF]

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Antitrypsin phenotyping

Heikki Savolainen   (11 April 2008)

Antitrypsin phenotyping 11 April 2008
Heikki Savolainen, Prof. Dept. of Occup. Safety & Hlth., Tampere, Finland Send letter to journal: Re: Antitrypsin phenotyping heikki.savolainen{at}stm.fi Heikki Savolainen	Antitrypsin screening by the determination of the phenotype is a very good idea. Phenotyping may be more useful than genotyping, only, as the antitrypsin peptide is also an acute phase protein so that the phenotype and activity could help in the diagnostic process of inflammatory conditions (1). The S heterozygosity seems to play a role in the bronchial hyperreactivity, and the heterozygosity in general may predispose to bronchopulmonary disease in the occupational exposure to organic diisocyanates (2). 1 Berode M, Savolainen H. Rev Méd Suisse Rom 1994; 114: 357-360 2 Berode M, Jost M, Ruegger M, Savolainen H. Int Arch Occup Environ Hlth 2005; 78: 158-163