SUPPLEMENT

Introduction : Lung Genetics, Genomics, and Gene Therapy

David M. Rodman and Mark W. Geraci
Chest 121: 1S. [Full Text] [PDF]  

Genetic Epidemiology of COPD

Edwin K. Silverman
Chest 121: 1S-6S. [Full Text] [PDF]  

Oligonucleotide Microarray Analysis of Lung Adenocarcinoma in Smokers and Nonsmokers Identifies GPC3 as a Potential Lung Tumor Suppressor

Charles A. Powell, Guoliang Xu, Jorge Filmus, Steven Busch, Jerome S. Brody, and Paul B. Rothman
Chest 121: 6S-7S. [Full Text] [PDF]  

Differential Gene Expression of sFRP-1 and Apoptosis in Pulmonary Emphysema

Kazushi Imai and Jeanine D’Armiento
Chest 121: 7S. [Full Text] [PDF]  

Asthma Genetics

William Osmond Charles Cookson
Chest 121: 7S-13S. [Abstract] [Full Text] [PDF]  

Genetic Analysis of Antigen-Induced Airway Manifestations of Asthma Using Recombinant Congenic Mouse Strains

Antoon J.M. Van Oosterhout, Prescilla V. Jeurink, Peter C. Groot, Gerard A. Hofman, Frans P. Nijkamp, and Peter Demant
Chest 121: 13S. [Full Text] [PDF]  

Sarcoidosis : Association With Human Leukocyte Antigen Class II Amino Acid Epitopes and Interaction With Environmental Exposures

Milton Rossman, Bruce Thompson, Margaret Frederick, Boyani Cizman, Eleni Magira, and Dimitri Monos
Chest 121: 14S. [Full Text] [PDF]  

The Genetic Predisposition to Interstitial Lung Disease : Functional Relevance

R. M. du Bois
Chest 121: 14S-20S. [Full Text] [PDF]  

Mutations in the Surfactant Protein C Gene Associated With Interstitial Lung Disease

Lawrence M. Nogee, Alston E. Dunbar, III, Susan Wert, Frederic Askin, Aaron Hamvas, and Jeffrey A. Whitsett
Chest 121: 20S-21S. [Full Text] [PDF]  

Mapping Susceptibility Genes for the Induction of Pulmonary Fibrosis in Mice

Richard K. Barth, LeRoy A. Hanchett, and Clare M. Baecher-Allan
Chest 121: 21S. [Full Text] [PDF]  

Uses of Expression Microarrays in Studies of Pulmonary Fibrosis, Asthma, Acute Lung Injury, and Emphysema : Roger S. Mitchell Lecture

Dean Sheppard
Chest 121: 21S-25S. [Abstract] [Full Text] [PDF]  

Allelic Imbalance Demonstrated by Microsatellite Analysis of Lung Samples From Patients With Familial Pulmonary Fibrosis

Alan Q. Thomas, Jennifer Carneal, Cheryl Markin, Kirk B. Lane, John A. Phillips, III, and James E. Loyd
Chest 121: 25S. [Full Text] [PDF]  

Overexpression of Matrix Metalloproteinase-7 in Pulmonary Fibrosis

Gregory P. Cosgrove, Marvin I. Schwarz, Mark W. Geraci, Kevin K. Brown, and G. Scott Worthen
Chest 121: 25S-26S. [Full Text] [PDF]  

Identification of Differentially Expressed Genes in a Monkey Model of Allergic Asthma by Microarray Technology

Jun Zou, Simon Young, Feng Zhu, Lu Xia, Susan Skeans, Yuntao Wan, Luquan Wang, Terri McClanahan, Ferdous Gheyas, Din Wei, Charles Garlisi, James Jakway, and Shelby Umland
Chest 121: 26S-27S. [Full Text] [PDF]  

Epidemiologic Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy

Francine Kauffmann, Marie-Hélène Dizier, Marie-Pierre Oryszczyn, Nicole Le Moual, Valérie Siroux, Isabella Annesi-Maesano, Jean Bousquet, Denis Charpin, Josué Feingold, Frédéric Gormand, Alain Grimfeld, Joelle Hochez, Mark Lathrop, Régis Matran, Françoise Neukirch, Evelyne Paty, Isabelle Pin, and Florence Demenais
Chest 121: 27S. [Full Text] [PDF]  

Molecular and Physiologic Evidence for 5'CpG Island Methylation of the Endothelin B Receptor Gene in Lung Cancer

Andrea J. Cohen, Steven Belinsky, Wilbur Franklin, and Scott Beard
Chest 121: 27S-28S. [Full Text] [PDF]  

Proteomic Analysis of Mouse Lung Neoplasia

Katherine Peebles, Kim Fung, Al Malkinson, and Mark Duncan
Chest 121: 28S. [Full Text] [PDF]  

Partial Pneumonectomy Enhances Melanoma Metastasis to Mouse Lungs

Lynn M. Brown, Danny R. Welch, D. Eugene Rannels, and Stephen R. Rannels
Chest 121: 28S-29S. [Full Text] [PDF]  

Microarray Identifies Cyclo-oxygenase-2–Dependent Modulation of Insulin-like Growth Factor Binding Protein-3 in Non-small Cell Lung Cancer Cells

Mehis Põld, M. Dohadwala, J. Luo, Y. Lin, and S. Dubinett
Chest 121: 29S-30S. [Full Text] [PDF]  

Familial Pulmonary Fibrosis in the United States

Momen M. Wahidi, Marcy C. Speer, Mark P. Steele, Kevin K. Brown, Marvin I. Schwarz, and David A. Schwartz
Chest 121: 30S. [Full Text] [PDF]  

Integrin-Mediated Regulation of Connexin 43 Expression by Alveolar Epithelial Cells

Yihe Guo, Cara Martinez-Williams, and D. Eugene Rannels
Chest 121: 30S-31S. [Full Text] [PDF]  

Identifying Fibrosis Susceptibility Genes in Two Strains of Inbred Mice

Arnold R. Brody, G. Sakuntala Warshamana, Jing-Yao Liu, Shang-Yi Tsai, Derek A. Pociask, David M. Brass, and David Schwartz
Chest 121: 31S. [Full Text] [PDF]  

Use of Oligonucleotide Microarrays to Analyze Gene Expression Patterns in Pulmonary Fibrosis Reveals Distinct Patterns of Gene Expression in Mice and Humans

Naftali Kaminski, Fengrong Zuo, Gady Cojocaro, Zohar Yakhini, Amir Ben-Dor, David Morris, Dean Sheppard, Annie Pardo, Moises Selman, and Renu A. Heller
Chest 121: 31S-32S. [Full Text] [PDF]  

Induction of Cyclo-oxygenase-2 in Non-small Cell Lung Cancer cells by Adenovirus Vector Infection

Edward A. Hirschowitz, Giovanna E. Hidalgo, and Dennis E. Doherty
Chest 121: 32S. [Full Text] [PDF]  

Towards an Effective Gene Therapy for Idiopathic Pulmonary Fibrosis : Anti-inflammation, Antifibrosis, and Regeneration

Masahito Ebina, M. Shimizukawa, K. Narumi, M. Miki, D. Koinuma, M. Watanabe, H. Munakata, and T. Nukiwa
Chest 121: 32S-33S. [Full Text] [PDF]  

Acute Lung Injury Does Not Impair Adenoviral-Mediated Gene Transfer to the Alveolar Epithelium

Vidas Dumasius, Michael Mendez, Gökhan M. Mutlu, and Phillip Factor
Chest 121: 33S-34S. [Full Text] [PDF]  

Adenovirally Mediated Expression of Urokinase Receptor Binding Site on Integrin -Chain Blocks Adhesion and Migration of Human Lung Fibroblasts

Sha Zhu, Candece L. Gladson, Jerry Stewart, Kimberly E. White, Harold A. Chapman, Jr., and Mitchell A. Olman
Chest 121: 34S-35S. [Full Text] [PDF]  

Enhancement of Adenovirus-Mediated Gene Transfer in Lungs and Epithelial Cells by EGTA

Carpantato Myles, Eric Sorscher, and Sadis Matalon
Chest 121: 35S. [Full Text] [PDF]  

Culturing Alveolar Type I, Alveolar Type II, and Mixed Cell Populations by Altering the Extracellular Matrix Promotes Changes in Intercellular Signaling Mechanisms

Scott Boitano, Brant E. Isakson, and Richard L. Lubman
Chest 121: 35S-36S. [Full Text] [PDF]  

Pseudomonas-Epithelial Cell Interactions Dissected With DNA Microarrays

Stephen Lory and Jeffrey K. Ichikawa
Chest 121: 36S-40S. [Full Text] [PDF]  

Pseudomonas aeruginosa-Human Airway Epithelial Cell Interaction : Effects of Iron on Inflammation and Apoptosis

Milene Saavedra, Michael Vasil, Scott Randell, James West, and David Rodman
Chest 121: 40S-42S. [Full Text] [PDF]  

Application of Expression Profiling to the Developing Lung : Thomas A. Neff Lecture

Thomas J. Mariani and Steven D. Shapiro
Chest 121: 42S-44S. [Abstract] [Full Text] [PDF]  

Transcriptional Profiling of Non-small Cell Lung Cancer Using Oligonucleotide Microarrays

Gady Cojocaru, Nir Friedman, Meir Krupsky, Penina Yaron, David Simansky, Alon Yellin, Gideon Rechavi, Yossef Barash, Amir Ben-Dor, Zohar Yakhini, and Naftali Kaminski
Chest 121: 44S. [Full Text] [PDF]  

Enhancement of Alveolar Epithelial ß₂-Adrenergic Receptor Function Via Gene Transfer

Phillip Factor, Zaher A. Azzam, Gökhan M. Mutlu, Jacob I. Sznajder, and Vidas Dumasius
Chest 121: 45S-46S. [Full Text] [PDF]  

Genetics and Gene Expression in Pulmonary Hypertension : Parker B. Francis Lecture

James E. Loyd
Chest 121: 46S-50S. [Full Text] [PDF]  

Bone Morphogenetic Protein Receptor 2 Mutations in Pulmonary Hypertension

Jane H. Morse
Chest 121: 50S-53S. [Full Text] [PDF]  

Linkage Analysis in a Large Family With Primary Pulmonary Hypertension : Genetic Heterogeneity and a Second Primary Pulmonary Hypertension Locus on 2q31–32

Bart Janssen, Matthias Rindermann, Ulrike Barth, Gabriel Miltenberger-Miltenyi, Derliz Mereles, Adel Abushi, Werner Seeger, Wolfgang Kübler, Claus R. Bartram, and Ekkehard Grünig
Chest 121: 54S-56S. [Full Text] [PDF]  

Genetics and Gene Expression in Lymphangioleiomyomatosis : Giles F. Filley Lecture

Gustavo Pacheco-Rodriguez, Arnold S. Kristof, Linda A. Stevens, Yi Zhang, Denise Crooks, and Joel Moss
Chest 121: 56S-61S. [Abstract] [Full Text] [PDF]  

Pulmonary Cysts Consistent With Lymphangioleiomyomatosis Are Common in Women With Tuberous Sclerosis : Genetic and Radiographic Analysis

Francis McCormack, Alan Brody, Christopher Meyer, Jennifer Leonard, Gail Chuck, Sandra Dabora, Gopalan Sethuraman, Thomas V. Colby, David J. Kwiatkowski, and David N. Franz
Chest 121: 61S. [Full Text] [PDF]  

Microsatellite Mutational Analysis of Endothelial Cells Within Plexiform Lesions From Patients With Familial, Pediatric, and Sporadic Pulmonary Hypertension

Michael E. Yeager, Heiko. A. Golpon, Norbert F. Voelkel, and Rubin M. Tuder
Chest 121: 61S. [Full Text] [PDF]  

The Genetics of Innate Immunity

David A. Schwartz
Chest 121: 62S-68S. [Abstract] [Full Text] [PDF]  

Genetic Polymorphisms Associated With Susceptibility and Outcome in ARDS

Richard P. Marshall, Suzanne Webb, Mike R. Hill, Steve E. Humphries, and Geoffrey J. Laurent
Chest 121: 68S-69S. [Full Text] [PDF]  

Microarray Analysis Indicates That Pulmonary Edema Fluid From Patients With Acute Lung Injury Mediates Inflammation, Mitogen Gene Expression, and Fibroblast Proliferation Through Bioactive Interleukin-1

Mitchell A. Olman, Kimberly E. White, Lorraine B. Ware, Michael T. Cross, Sha Zhu, and Michael A. Matthay
Chest 121: 69S-70S. [Full Text] [PDF]  

Acute Lung Injury : Functional Genomics and Genetic Susceptibility

George D. Leikauf, Susan A. McDowell, Scott C. Wesselkamper, William D. Hardie, John E. Leikauf, Thomas R. Korfhagen, and Daniel R. Prows
Chest 121: 70S-75S. [Abstract] [Full Text] [PDF]  

Lipopolysaccharide Stimulation of the Human Neutrophil : An Analysis of Changes in Gene Transcription and Protein Expression by Oligonucleotide Microarrays and Proteomics

Michael B. Fessler, Kenneth C. Malcolm, Mark William Duncan, and G. Scott Worthen
Chest 121: 75S-76S. [Full Text] [PDF]  

Lipopolysaccharide-Induced Neutrophil Gene Expression Under In Vivo or In Vitro Conditions

John Arcaroli, John Kupfner, Ho-Kee Yum, Robert Shenkar, Jong Sung Park, and Edward Abraham
Chest 121: 76S-77S. [Full Text] [PDF]  

Role of Keratinocyte Growth Factor in Regulating Lipogenesis in Alveolar Type II Cells : A Gene-Profiling Approach

Robert J. Mason, Bifeng Gao, Tianli Pan, Xiaoqiao Jiang, Michael Eckart, and Steven Neben
Chest 121: 77S. [Full Text] [PDF]  

Identification of Novel Target Proteins in Th2-Dominated Allergic Inflammatory Responses Using Complementary DNA Representational Difference Analysis and Complementary DNA Microarrays

Peter C. Groot, B. Jerden Van Bergenhenegouwen, Frans P. Nijkamp, and Antoon J. M. Van Oosterhout
Chest 121: 77S-78S. [Full Text] [PDF]  

Up-regulation of Angiogenic Factor Expression in Hypoxia-Treated Mouse Lung Demonstrated By DNA Array Technique

Dechun Li, Xingwu Teng, and Roger A. Johns
Chest 121: 78S. [Full Text] [PDF]  

Subtractive Hybridization Analysis of Pneumocystis carinii Gene Activation Induced by Interaction With Lung Epithelial Cells and Matrix

Theodore J. Kottom and Andrew H. Limper
Chest 121: 78S-79S. [Full Text] [PDF]  

Secretion-Competent Mouse Tracheal Epithelial Cell Culture From the Genetically Altered Mouse : Pathway Analysis Via Gene Array

Linda D. Martin, Kenneth B. Adler, Nancy J. Akley, Anne Crews, and Lioudmila Sharova
Chest 121: 79S. [Full Text] [PDF]  

Gene Expression in an In Vitro Model of Epithelial Repair

John Spurzem, Ji Zhang PhD, Xiang-der Liu, Stephan I. Rennard, and Debra V. Romberger
Chest 121: 79S-80S. [Full Text] [PDF]  

Use of Spotted Oligonucleotide Arrays for Large-Scale Analysis of Mammalian Gene Expression

David J. Erle, Laura Koth, Oren Abramson, Madeleine W. Rodriguez, and Andrea Barczak
Chest 121: 80S. [Full Text] [PDF]  

Microarray Analysis of Gene Expression in the Embryonic Lung

Sui Lin and John M. Shannon
Chest 121: 80S-81S. [Full Text] [PDF]  

Genetic and Environmental Risk Factors in Beryllium Sensitization and Chronic Beryllium Disease

Lisa Maier, John Martyny, Margaret Mroz, Diedre McGrath, Penny Lympany, Roland duBois, Lenning Zhang, James Murphy, and Lee S. Newman
Chest 121: 81S. [Full Text] [PDF]  

Primary Pulmonary Hypertension Is Predominantly a Hereditary Disease

E. Grünig, D. Mereles, K. Arnold, A. Benz, Horst Olschewski, G. Miltenberger-Miltenyi, M. M. Borst, A. Abushi, W. Seeger, J. Winkler, M. M. Höper, C. R. Bartram, W. Kübler, and B. Janssen
Chest 121: 81S-82S. [Full Text] [PDF]  

Quantitative Trait Loci That Regulate Susceptibility to Both Butylated Hydroxytoluene-Induced Pulmonary Inflammation and Lung Tumor Promotion in CXB Recombinant Inbred Mice

Al Malkinson, Richard Radcliffe, Alison Bauer, Lori Dwyer-Nield, and Steven Kleeberger
Chest 121: 82S. [Full Text] [PDF]  

Hypoxia Up-regulates Mouse Vascular Endothelial Growth Factor D Promoter Activity in Rat Pulmonary Microvascular Smooth-Muscle Cells

Xingwu Teng, Dechuan Li, and Roger A. Johns
Chest 121: 82S-83S. [Full Text] [PDF]  

Specific Bone Morphogenic Protein Receptor II Mutations Found in Primary Pulmonary Hypertension Cause Different Biochemical Phenotypes In Vitro

Alan Q. Thomas, Jennifer Carneal, Cheryl Markin, Kirk B. Lane, John A. Phillips, III, James E. Loyd, and Radhika Gaddipati
Chest 121: 83S. [Full Text] [PDF]  

Pulmonary Gene Expression Profiles of Spontaneously Hypertensive Rats Exposed to Environmental Tobacco Smoke

Srikanth S. Nadadur, Kent E. Pinkerton, and Urmila P. Kodavanti
Chest 121: 83S-84S. [Full Text] [PDF]  

Interleukin-18 Expression in Cystic Fibrosis Lungs

Edward D. Chan, Hyung-Seok Choi, Carlyne Cool, Frank J. Accurso, and Giamila Fantuzzi
Chest 121: 84S-85S. [Full Text] [PDF]  

Intracellular Adhesion Molecule Gly241Arg Polymorphism Has No Impact on ARDS or Septic Shock in Community-Acquired Pneumonia

Michael W. Quasney, Grant W. Waterer, Mary K. Dahmer, Dawn Turner, Qing Zhang, Rita M. Cantor, and Richard G. Wunderink
Chest 121: 85S-86S. [Full Text] [PDF]  

Impact of Cytokine Gene Polymorphisms on Outcomes of Coronary Artery Bypass Graft Surgery

Sachin Yende, Michael Quasney, Q. Zhang, Kristi Frederick, Lori Kessler, and Richard G. Wunderink
Chest 121: 86S. [Full Text] [PDF]  

Tumor Necrosis Factor Gene Polymorphisms and the Variable Presentation and Outcome of Community-Acquired Pneumonia

Richard G. Wunderink, Grant W. Waterer, Rita M. Cantor, and Michael W. Quasney
Chest 121: 87S. [Full Text] [PDF]  

High and Low Inflammatory Response Phenotypes in 101 Normal Human Subjects

William Y. Park, C. W. Frevert, V. A. Wong, and T. R. Martin
Chest 121: 87S-88S. [Full Text] [PDF]  

Roles of Interleukin-13 and Interferon- in Lung Inflammation

Gabriele Grünig, Jean G. Ford, Debra D. Donaldson, Rajeev Venkayya, Cliff McArthur, Elisabeth Hansell, Viswanath A. Kurup, Martha Warnock, and Donna Rennick
Chest 121: 88S. [Full Text] [PDF]  

A Search for Linkage to Atopic Asthma in Candidate Regions in a Danish Population

Charlotte Brasch Andersen, Dorte Larsen, Annette Haagerup, Joergen Vestbo, and Torben A. Kruse
Chest 121: 88S-89S. [Full Text] [PDF]  

Impaired Clearance of Apoptotic Cells From Cystic Fibrosis Airways

R. William Vandivier, Valerie A. Fadok, Carol Anne Ogden, Peter R. Hoffmann, Joseph D. Brain, Frank J. Accurso, James H. Fisher, Kelly E. Greene, and Peter M. Henson
Chest 121: 89S. [Full Text] [PDF]  

Regulation of Vascular Smooth Muscle Cell Growth and Adhesion by Paired-Related Homeobox Genes

Frederick S. Jones, David M. McKean, Robyn Meech, David B. Edelman, Rebecca J. Oakey, and Peter Lloyd Jones
Chest 121: 89S-90S. [Full Text] [PDF]  

Application of Expression Microarrays to the Investigation of Fetal Lung Development in a Glucocorticoid Receptor Knockout Mouse Model

Feige Kaplan, Tara MacRae, Julie Comber, Stephane Gagnon, Robert Sladek, Thomas J. Hudson, and Neil B. Sweezey
Chest 121: 90S. [Full Text] [PDF]  

Gene Therapy of Mucus Hypersecretion in Experimental Asthma

Christopher Evans, Farrah Kheradmand, David Corry, Michael Tuvim, Charles Densmore, Clifford Waldrep, Vernon Knight, and Burton Dickey
Chest 121: 90S-91S. [Full Text] [PDF]  

Mode of Action of RNA/DNA Oligonucleotides : Progress in the Development of Gene Repair as a Therapy for ₁-Antitrypsin Deficiency

Richard Metz, Mike DiCola, Takao Kurihara, Austin Bailey, Bruce Frank, Bryan Roecklein, and Michael Blaese
Chest 121: 91S-97S. [Abstract] [Full Text] [PDF]  

Mutations in DNAI1 (IC78) Cause Primary Ciliary Dyskinesia

Peadar G. Noone, Maimoona Zariwala, Aruna Sannuti, Susan Minnix, Margaret W. Leigh, Johnny Carson, and Michael R. Knowles
Chest 121: 97S. [Full Text] [PDF]  

Hyperplasia of Pulmonary Artery Smooth Muscle Cells Is Causally Related to Overexpression of the Serotonin Transporter in Primary Pulmonary Hypertension

Saadia Eddahibi, Marc Humbert, Elie Fadel, Bernadette Raffestin, Michèle Darmon, Frédérique Capron, Gérald Simonneau, Philippe Dartevelle, Michel Hamon, and Serge Adnot
Chest 121: 97S-98S. [Full Text] [PDF]  

Recombinant Adeno-Associated Virus Gene Therapy for Cystic Fibrosis and ₁-Antitrypsin Deficiency

Terence R. Flotte
Chest 121: 98S-102S. [Full Text] [PDF]  

Cyclooxygenase-2 Overexpression, Using an Integrin-Targeted Gene Delivery System (the LID Vector), Inhibits Fibroblast Proliferation In Vitro and Leads to Increased Prostaglandin E₂ in the Lung

Gisli Jenkins, Stephen L. Hart, Rebecca J. Hodges, Qin-Hai Meng, Christine Kinnon, Geoffrey J. Laurent, and Robin J. McAnulty
Chest 121: 102S-104S. [Full Text] [PDF]  

Gene Expression Profiles in Pulmonary Hypertension

Mark W. Geraci, Yasushi Hoshikawa, Michael Yeager, Heiko Golpon, Tracy Gesell, Rubin M. Tuder, and Norbert F. Voelkel
Chest 121: 104S-105S. [Full Text] [PDF]  

Pulmonary Genetics, Genomics, and Gene Therapy : Conference Summary

Steven M. Albelda
Chest 121: 105S-110S. [Full Text] [PDF]  

Conference Sponsors : Advanced Medicine, Inc.

Chest 121: 111S. [Full Text] [PDF]  

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