SUPPLEMENT

Cellular and Molecular Mechanisms of Pulmonary Hypertension Beyond Vasodilators

Rubin M. Tuder, Norbert F. Voelkel, and Karen A. Fagan
Chest 128: e1S-e2S [Full Text]  

Phenotypic Characterization of Pulmonary Arteries in Normal and Diseased Lung

Michael Kasper
Chest 128: 547S-552S [Abstract] [Full Text] [PDF]  

Serotonin Transporter and Receptors in Various Forms of Human Pulmonary Hypertension

Elisabeth Marcos, Elie Fadel, Olivier Sanchez, Marc Humbert, Philippe Dartevelle, Gerald Simonneau, Michel Hamon, Serge Adnot, and Saadia Eddahibi
Chest 128: 552S-553S [Full Text] [PDF]  

Suppression of Type II Bone Morphogenic Protein Receptor in Vascular Smooth Muscle Induces Pulmonary Arterial Hypertension in Transgenic Mice

James West, Yuji Tada, Karen A. Fagan, Wolfgang Steudel, Brian W. Fouty, Julie Wright Harral, Marloes Miller, John Ozimek, Rubin M. Tuder, and David M. Rodman
Chest 128: 553S [Full Text] [PDF]  

Alveolocapillary Cross-Talk: Giles F. Filley Lecture

Jahar Bhattacharya
Chest 128: 553S-555S [Full Text] [PDF]  

Superoxide and Chronic Hypoxia-Induced Pulmonary Hypertension in Newborn Piglets

Candice D. Fike, Judy L. Aschner, Yongmei Zhang, Daniela Salvemini, and Mark R. Kaplowitz
Chest 128: 555S-556S [Full Text] [PDF]  

Redox Activation of Intracellular Calcium Release Channels (Ryanodine Receptors) in the Sustained Phase of Hypoxia-Induced Pulmonary Vasoconstriction

Wanglei Du, Melissa Frazier, Timothy J. McMahon, and Jerry P. Eu
Chest 128: 556S-558S [Abstract] [Full Text] [PDF]  

Molecular and Cellular Determinants of Lung Endothelial Cell Heterogeneity

Troy Stevens
Chest 128: 558S-564S [Abstract] [Full Text] [PDF]  

The Extracellular Matrix Microenvironment Specifies Pulmonary Endothelial Cell Identity: Roles of Tenascin-C and RhoA

Lila Sisbarro, Kaori Ihida-Stansbury, Troy Stevens, Natalie Bauer, Ivan McMurtry, and Peter Lloyd Jones
Chest 128: 564S [Full Text] [PDF]  

Aberrant Signal Transduction In Pulmonary Hypertension

Kirk B. Lane, Thomas R. Blackwell, James Runo, Lisa Wheeler, John A. Phillips, III, and James E. Loyd
Chest 128: 564S-565S [Full Text] [PDF]  

Pulmonary Hypertension: Cellular and Molecular Mechanisms

Carlyne D. Cool, Steve D. Groshong, John Oakey, and Norbert F. Voelkel
Chest 128: 565S-571S [Full Text] [PDF]  

Definitive Evidence of Fundamental and Inherent Alteration in the Phenotype of Primary Pulmonary Hypertension Endothelial Cells in Angiogenesis

Fares A. Masri, Bela Anand-Apte, Amit Vasanji, Weiling Xu, Tannishia Goggans, Judith Drazba, and Serpil C. Erzurum
Chest 128: 571S [Full Text] [PDF]  

The Protective Role of T-Lymphocytes in Pulmonary Vascular Remodeling

L. Taraseviciene-Stewart, D. Kraskauskas; R. Scerbavicius, N. Burns, Carlyne D. Cool, Mark R. Nicolls, and Norbert F. Voelkel
Chest 128: 571S-572S [Full Text] [PDF]  

Matrix Metalloproteinases in the Urine of Patients With Pulmonary Arterial Hypertension

Jacques I. Benisty, Judah Folkman, David Zurakowski, Gwendolyn Louis, Stuart Rich, David Langleben, and Marsha A. Moses
Chest 128: 572S [Full Text] [PDF]  

Interleukin-6 Causes Mild Pulmonary Hypertension and Augments Hypoxia-Induced Pulmonary Hypertension in Mice

Scott M. Golembeski, James West, Yuji Tada, and Karen A. Fagan
Chest 128: 572S-573S [Full Text] [PDF]  

The Role of p38 Mitogen-Activated Protein Kinase in Hypoxia-Induced Vascular Cell Proliferation: An Interspecies Comparison

David Welsh, Heather Mortimer, Alan Kirk, and Andrew Peacock
Chest 128: 573S-574S [Full Text] [PDF]  

Effects of Simvastatin on Cigarette Smoking-Induced Structural and Functional Changes in Rat Lungs

Sang Do Lee, Ji-Hyun Lee, Eun Kyung Kim, Kang-Hyun Choi, Yeon Mok Oh, and Tae Sun Shim
Chest 128: 574S [Full Text] [PDF]  

The Expression of Prostacyclin Synthase Is Decreased in the Small Pulmonary Arteries From Patients With Emphysema

Jong Deog Lee, Laima Taraseviciene-Stewart, Robert Keith, Mark W. Geraci, and Norbert F. Voelkel
Chest 128: 575S [Full Text] [PDF]  

Pulmonary Capillary Hemangiomatosis*: Results of Gene Expression Analysis

Steven M. Kawut, Adel M. Assaad, Selim M. Arcasoy, Erika B. Rosenzweig, Joshua R. Sonett, and Alain C. Borczuk
Chest 128: 575S-576S [Full Text] [PDF]  

Pulmonary Capillary Hemangiomatosis: An Immunohistochemical Analysis of Vascular Remodeling in a Fatal Case

Andrew Sullivan, Kathryn Chmura, Carlyne D. Cool, Norbert Voelkel, and Edward D. Chan
Chest 128: 576S [Full Text] [PDF]  

Protein Kinase C Inhibits Cyclic Adenosine Monophosphate-Induced Calcium-Activated and Voltage-Activated Potassium Channel Activity in Fawn-Hooded Rat Pulmonary Arterial Smooth Muscle Via Phosphodiesterases

Scott. A. Barman, Shu Zhu, Mary L. Meadows, and Richard. E. White
Chest 128: 576S [Full Text] [PDF]  

Mts1/S100A4 Stimulates Human Pulmonary Artery Smooth Muscle Cell Migration Through Multiple Signaling Pathways

Edda Spiekerkoetter, Allan Lawrie, Sandra Merklinger, Noona Ambartsumian, Eugene Lukanidin, Ann-Marie Schmidt, and Marlene Rabinovitch
Chest 128: 577S [Full Text] [PDF]  

Hypoxia Down-Regulates Cyclic Guanidine Monophosphate-Dependent Protein Kinase in Fetal Pulmonary Vascular Smooth Muscle Cell Through Generation of Reactive Oxygen Species and Promotes Development of Pulmonary Hypertension

Fred Sander, Yuansheng Gao, and J. Usha Raj
Chest 128: 577S-578S [Full Text] [PDF]  

Mechanisms of Heme Oxygenase-1-Mediated Cardiac and Pulmonary Vascular Protection in Chronic Hypoxia: Roles of Carbon Monoxide and Bilirubin

Sally H. Vitali, S.A. Mitsialis, Helen Christou, Angeles Fernandez-Gonzalez;, Xianlan Liu, and Stella Kourembanas
Chest 128: 578S-579S [Full Text] [PDF]  

Differential Gene Expression in Chronic Hypoxic Pulmonary Hypertension: Effect of Simvastatin Treatment

Reda E. Girgis, S.F. Ma, S. Ye, D.N. Grigoryev, Dechun Li, Paul M. Hassoun, Rubin M. Tuder, Roger A. Johns, and Joe G.N. Garcia
Chest 128: 579S [Full Text] [PDF]  

Attenuation of Hypoxia-Induced Pulmonary Artery Remodeling by a Peroxisome Proliferator-Activated Receptor- Agonist

Joseph T. Crossno, Jr, Kenneth G. Morris, Jr, and Dwight J. Klemm
Chest 128: 580S [Full Text] [PDF]  

Endothelin-B Receptor Overexpression Prevents Hypoxic Pulmonary Hypertension in Cirrhotic Rats

Masatoshi Imamura, Andrea M. Vitello, Jennifer N. Limbird, D. Dunbar Ivy, Michael B. Fallon, and Ethan P. Carter
Chest 128: 580S-581S [Full Text] [PDF]  

The Low-Voltage-Activated Calcium Channel CAV3.1 Controls Proliferation of Human Pulmonary Artery Myocytes

D.M. Rodman, J. Harral, S. Wu, J. West, M. Hoedt-Miller, K.A. Reese, and K. Fagan
Chest 128: 581S-582S [Full Text] [PDF]  

Hypoxia-Induced Alterations in Protein Kinase C Signaling Result in Augmented Fibroblast Proliferation

Megan Short, Stephanie Fox, Kurt R. Stenmark, and Mita Das
Chest 128: 582S [Full Text] [PDF]  

Role of Rho in the Increased Migration of Pulmonary Artery Smooth Muscle Cells Observed in the Neprilysin Knockout Mouse

Vijaya Karoor, Sandra J. Walchak, York E. Miller, and Edward C. Dempsey
Chest 128: 582S-583S [Full Text] [PDF]  

Circulating Mononuclear Cells With a Dual, Macrophage-Fibroblast Phenotype Contribute Robustly to Hypoxia-Induced Pulmonary Adventitial Remodeling

Maria G. Frid, Jacqueline A. Brunetti, Danielle L. Burke, Todd C. Carpenter, Neil J. Davie, and Kurt R. Stenmark
Chest 128: 583S-584S [Full Text] [PDF]  

Microarray Analysis of Peripheral Blood Cells in Pulmonary Arterial Hypertension, Surrogate to Biopsy

Todd M. Bull, Chris D. Coldren, Patrick Nana-Sinkam, Sylk M. Sotto-Santiago, Mark Moore, Norbert F. Voelkel, and Mark W. Geraci
Chest 128: 584S [Full Text] [PDF]  

Transforming Growth Factor-ß Signal Transduction in Angiogenesis and Vascular Disorders

Philippe Bertolino, Martine Deckers, Franck Lebrin, and Peter ten Dijke
Chest 128: 585S-590S [Abstract] [Full Text] [PDF]  

Bone Morphogenetic Protein 4 Promotes Vascular Remodeling in Hypoxic Pulmonary Hypertension

David Frank, Joyce Johnson, and Mark de Caestecker
Chest 128: 590S-591S [Full Text] [PDF]  

Regulation and Functions of the Paired-Related Homeobox Gene PRX1 in Pulmonary Vascular Development and Disease

K. Ihida-Stansbury, D.M. McKean, S.A. Gebb, J.F. Martin, T. Stevens, R. Nemenoff, J. Vaughn, K. Lane, J. Loyd, L. Wheeler, N.W. Morrell, D. Ivy, and P.L. Jones
Chest 128: 591S [Full Text] [PDF]  

Involvement of Hypoxia-Inducible Factor 1 in Pulmonary Pathophysiology

Gregg L. Semenza
Chest 128: 592S-594S [Abstract] [Full Text] [PDF]  

Chronic Hypoxia-Enhanced Murine Pulmonary Vasoconstriction: Role of Superoxide and gp91^phox

John Q. Liu, Efua M. Erbynn, and Rodney J. Folz
Chest 128: 594S-596S [Abstract] [Full Text] [PDF]  

Phenotypic Diversity of the Lung Vasculature in Experimental Models of Metastases

Yun Oh, Imran Mohiuddin, Yan Sun, Joseph B. Putnam, Jr, Waun Ki Hong, Wadih Arap, and Renata Pasqualini
Chest 128: 596S-600S [Abstract] [Full Text] [PDF]  

Hypoxia Amplifies the Proliferative Capacity of Distal Human Pulmonary Artery Smooth-Muscle Cells

Ellena J. Growcott, Kathy H. Banner, and John Wharton
Chest 128: 600S-601S [Full Text] [PDF]  

Abnormal Vascular Phenotypes in Patients With Idiopathic Pulmonary Fibrosis and Secondary Pulmonary Hypertension

James Gagermeier, James Dauber, Samuel Yousem, Kevin Gibson, and Naftali Kaminski
Chest 128: 601S [Full Text] [PDF]  

Does BMPR2 Mutation Disrupt Pulmonary Vasculogenesis?

Trina K. Jeffery, Paul D. Upton, X. Yang, M. Southwood, L. Long, R. C. Trembath, and Nicholas W. Morrell
Chest 128: 602S [Full Text] [PDF]  

Imaging of Angiogenesis in Inflamed Airways and Tumors: Newly Formed Blood Vessels Are Not Alike and May Be Wildly Abnormal: Parker B. Francis Lecture

Donald M. McDonald and Peter Baluk
Chest 128: 602S-608S [Full Text] [PDF]  

Extracellular Adenosine Triphosphate: A Potential Regulator of Vasa Vasorum Neovascularization in Hypoxia-Induced Pulmonary Vascular Remodeling^,*

Evgenia V. Gerasimovskaya, Neil J. Davie, Shama Ahmad, Doug A. Tucker, Carl W. White, and Kurt R. Stenmark
Chest 128: 608S-610S [Full Text] [PDF]  

Rho Guanosine Triphosphatases in Lung Development and Pulmonary Hypertension

Jonathan Kaufman, Eiko Sakao, Masahiko Oka, Tetsu Nagaoka, Cheryl K. Oliver-Picket, Peter L. Jones, Ivan F. McMurtry, and Sarah A. Gebb
Chest 128: 610S [Full Text] [PDF]  

Vascular Endothelial Growth Factor Receptor Blockade by SU5416 Combined With Pulsatile Shear Stress Causes Apoptosis and Subsequent Proliferation of Apoptosis-Resistant Endothelial Cells

Seiichiro Sakao, Laimute Taraseviciene-Stewart, Jong Deog Lee, Kathy Wood, Carlyne D. Cool, and Norbert F. Voelkel
Chest 128: 610S-611S [Full Text] [PDF]  

Genomic Threats From Physiological Signals in Lung Vascular Cells

Mark N. Gillespie, Kathryn A. Ziel, Valentina Grishko, Clayton C. Campbell, and Glenn L. Wilson
Chest 128: 611S-612S [Full Text] [PDF]  

Prostacyclin Synthase Promoter Regulation and Familial Pulmonary Arterial Hypertension

Patrick Nana-Sinkam, Ryan J. Oyer, R. S. Stearman, Sylk Sotto-Santiago, Mark D. Moore, Todd M. Bull, M. C. Grady, Q. Choudhery, Raphael A. Nemenoff, Kirk Lane, James E. Loyd, and Mark W. Geraci
Chest 128: 612S [Full Text] [PDF]  

Tissue Factor Is Induced in a Rodent Model of Severe Pulmonary Hypertension Characterized by Neointimal Lesions Typical of Human Disease

R. James White, Irfan I. Galaria, Jennifer Harvey, Burns C. Blaxall, Carlyne D. Cool, and Mark B. Taubman
Chest 128: 612S-613S [Full Text] [PDF]  

Inhaled Nitric Oxide Reverses Hypoxia Induced Lung Hypoplasia in Endothelial Nitric Oxide Synthase-Deficient Mice

Vivek Balasubramaniam, Anne Maxey, and Steven Abman
Chest 128: 613S-614S [Full Text] [PDF]  

Vascular Endothelial Growth Factor Improves Pulmonary Vascular Reactivity and Structure in an Experimental Model of Chronic Pulmonary Hypertension in Fetal Sheep

Theresa R. Grover, Thomas A. Parker, and Steven H. Abman
Chest 128: 614S [Full Text] [PDF]  

Comparative Analysis of BMPR2 Gene and Its Mutations in Idiopathic Pulmonary Arterial Hypertension

Wai P. K. Wong, James A. Knowles, and Jane H. Morse
Chest 128: 615S [Full Text] [PDF]  

Ventilation/Perfusion Ratios in Pulmonary Arterial Hypertension: Effects of IV and Inhaled Prostacyclin Derivatives

Tomas Bratel, Lars Lagerstrand, Lars-Åke Brodin, Jacek Nowak, and Ivar Randmaa
Chest 128: 615S-616S [Full Text] [PDF]  

Effects of Aerosol vs IV UT-15 on Prostaglandin H₂ Analog-Induced Pulmonary Hypertension in Sheep

Brett L. Sandifer, Kenneth L. Brigham, E. Clinton Lawrence, and Richard E. Parker
Chest 128: 616S [Full Text] [PDF]  

The Impact of Pulmonary Hypertension on Survival in Patients With Idiopathic Pulmonary Fibrosis

Hassan F. Nadrous, Patricia A. Pellikka, Michael J. Krowka, Karen L. Swanson, Nithima Chaowalit, Paul A Decker, and Jay H. Ryu
Chest 128: 616S-617S [Full Text] [PDF]  

Evidence for Systemic Endothelial Dysfunction in Patients and First-Order Relatives With Pulmonary Arterial Hypertension

R. Hughes, J. Tong, C. Oates, J. Lordan, and P.A. Corris
Chest 128: 617S [Full Text] [PDF]  

Bone Morphogenetic Protein Receptor 2 Mutations in Adults and Children With Idiopathic Pulmonary Arterial Hypertension: Association With Thyroid Disease^*

Kari E. Roberts, Robyn J. Barst, Jude J. McElroy, Allison Widlitz, Kiran Chada, James A. Knowles, and Jane H. Morse
Chest 128: 618S [Full Text] [PDF]  

Acute Cardiopulmonary Hemodynamic Effects of Brain Natriuretic Peptide in Patients With Pulmonary Arterial Hypertension

James R. Klinger, Jeanne Houtchens, Sejal Thaker, Nicholas S. Hill, and Harrison Farber
Chest 128: 618S-619S [Full Text] [PDF]  

Serotonin Transporter Gene Polymorphism in a Cohort of German Patients With Idiopathic Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension

Rolf Koehler, Horst Olschewski, Marius Hoeper, Bart Janssen, and Ekkehard Grünig
Chest 128: 619S [Full Text] [PDF]  

Metastatic Cancer While Receiving Continuous Prostacyclin Therapy

Karen A. Fagan, Todd M. Bull, David B. Badesch, and Norbert F. Voelkel
Chest 128: 619S-620S [Full Text] [PDF]  

Divergent Contractile and Structural Responses of the Murine Protein Kinase C- Null Pulmonary Circulation to Chronic Hypoxia

Cassana M. Littler, C.A. Wehling, K.A. Fagan, R.O. Messing, and E.C. Dempsey
Chest 128: 620S-621S [Full Text] [PDF]  

Osteopontin May Be Responsible for Pulmonary Vascular Remodeling

Yasushi Hoshikawa, Yasushi Matsuda, Satoshi Suzuki, Yoshinori Okada, Toshiharu Tabata, Yuji Matsumura, and Takashi Kondo
Chest 128: 621S [Full Text] [PDF]  

Evidence for Vascular Remodeling in the Lungs of Macaques Infected With Simian Immunodeficiency Virus/HIV NEF Recombinant Virus

John Marecki, Carlyne Cool, Norbert Voelkel, Paul Luciw, and Sonia Flores
Chest 128: 621S-622S [Full Text] [PDF]  

Pulmonary Endothelin-1 Clearance in Human Pulmonary Arterial Hypertension

David Langleben, J. Dupuis, A. Hirsch, M. Giovinazzo, I. Langleben, J. Khoury, N. Ruel, and A. Caron
Chest 128: 622S [Full Text] [PDF]  

Clinical Challenges in Pulmonary Hypertension: Roger S. Mitchell Lecture

Steeve Provencher, Xavier Jais, Azzedine Yaici, Olivier Sitbon, Marc Humbert, and Gérald Simonneau
Chest 128: 622S-628S [Abstract] [Full Text] [PDF]  

Interventricular Mechanical Asynchrony Due To Right Ventricular Pressure Overload in Pulmonary Hypertension Plays an Important Role in Impaired Left Ventricular Filling

Anton Vonk-Noordegraaf, Johan T. Marcus, C. Tji Gan, Anco Boonstra, and Pieter E. Postmus
Chest 128: 628S-630S [Full Text] [PDF]  

MRI Pulmonary Angiograms

Marc R. Pritzker, John Lesser, and Terrance Long
Chest 128: 630S [Full Text] [PDF]  

Enhanced Hypoxic Pulmonary Vasoconstriction in Families of Adults or Children With Idiopathic Pulmonary Arterial Hypertension

Ekkehard Grünig, Christoph Dehnert, Derliz Mereles, Rolf Koehler, Horst Olschewski, Peter Bärtsch, and Bart Janssen
Chest 128: 630S-633S [Full Text] [PDF]  

Role of Angiopoietin-1 in Experimental and Human Pulmonary Arterial Hypertension

Lakshmi Kugathasan, André E. Dutly, Yidan D. Zhao, Yupu Deng, Malcolm J. Robb, Shaf Keshavjee, and Duncan J. Stewart
Chest 128: 633S-642S [Abstract] [Full Text] [PDF]  

Cellular and Molecular Pathobiology of Pulmonary Hypertension Conference Summary

Marlene Rabinovitch
Chest 128: 642S-646S [Full Text] [PDF]  

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